The side effects of Zhewitra, including dizziness, headaches, and flushing, may be more pronounced in individuals with liver disease. These patients are at a heightened risk for experiencing these effects more intensely due to the slower clearance of the drug from their system. Patients with chronic liver disease often take multiple medications to manage their condition, such as antivirals or medications for liver function support. Zhewitra may interact with these drugs, either enhancing their effects or causing unforeseen interactions. This can complicate the management of both the liver disease and erectile dysfunction.